Saccharomyces Boulardii

Share on facebook
Share on twitter
Share on pinterest
Share on email
Saccharomyces Boulardii probiotic

Note: This article may contain affiliate links. If you click a link and purchase a product, Consumer’s Health Report may receive a commission, which allows us to continue to do our research.

Medically Reviewed by: Chris Duncombe, M.D.

Probiotics are made of microorganisms like yeast or bacteria and they aim to promote overall health by improving digestion. Saccharomyces boulardii, also referred to as S. boulardii and pronounced SAK-a-roe-MYE-sees-boo-LAR-dee, is a yeast found naturally in tropical plants.

What is Saccharomyces Boulardii?

Saccharomyces boulardii is sometimes used as a probiotic, and can be found in probiotic supplements, with the purpose of improving the overall health of the human intestinal tract. It also serves to provide protection to the intestinal walls by adhering to them, and blocking out harmful bacteria. Particularly proven to be found effective is S. boulardii.

Studies have shown that saccharomyces boulardii has probiotic properties and that “recent data has opened the door for new therapeutic uses of this yeast as an ‘immunobiotic'”, a term proposed to define microbial strains which may promote immune system health from within the gut, improving overall health of the body.[39]


Saccharomyces Boulardii was originally discovered in 1923 by French microbiologist Henri Boulard. Boulard was working in Indochina when he observed that locals consumed tea made with the tropical fruits lychee and mangosteen to ward off diarrhea caused by disease. Boulard was able to isolate the yeast strain saccharomyces from these fruits and named the strain of probiotic after himself, saccharomyces boulardii, or S. boulardii.[41]

Following the discovery of S. boulardiiEuropean scientists went to work studying its properties and found evidence that it could be useful in combating pathogenic organisms.[41] A plethora of studies are still being carried out to this day on saccharomyces boulardii and its health effects. There is still much to learn about this probiotic but there is evidence of its health benefits and very minimal side effects.

Where is it Found?

Saccharomyces boulardii is a strain of Saccharomyces cerevisiae (Bakers yeast). Saccharomyces boulardii can be found in supplements, sauerkraut, kimchi, sour pickles, kombucha, sour dough bread, yogurt, and more. You can also find it in supplement drinks.

Saccharomyces Boulardii Medical Effects On The Human Body

Treatment of Antibiotic-Associated Diarrhea

Various studies have found saccharomyces boulardii to be effective in the treatment of diarrhea. An analysis of 21 randomized trials among almost 4800 participants confirmed that saccharomyces boulardii is effective for reducing antibiotic associated and traveler’s diarrhea.[7][15][16]

  • A randomized controlled trial conducted by The Medical University of Warsaw found that patients who took saccharomyces boulardii orally had a lower prevalence of diarrhea during and up to two weeks after treatment. The researchers concluded that saccharomyces boulardii “effectively reduces the risk of antibiotic‐associated diarrhoea in children.”[37]
  • A systematic review and meta-analysis on saccharomyces boulardii in adult patients found evidence that saccharomyces boulardii reduced the side effects of H. pylori treatment and prevented enteral nutrition-related diarrhea. This study also found that it is “significantly effective” for treating adult acute diarrhea and traveler’s diarrhea. [40]

Treatment of Diarrhea Related to Illnesses

There have been several studies that show Saccharomyces boulardii may be helpful in treating diarrhea caused by other illnesses such as:

Clostridium difficile infection: In a study in children, S. boulardii reduced the risk of antibiotic-associated diarrhea caused by clostridium difficile. [16]

Acute gastroenteritis: Further studies support the benefit of S. boulardii in the reduction of antibiotic-associated diarrhea in hospitalized patients, C. difficile associated diarrhea in laboratory mice and traveller’s diarrhea. [8][12][20]

Helicobacter pylori infection: The addition of probiotics is associated with improved H. pylori eradication rates in both children and adults. [42]

Traveler’s diarrhea: anytime a person travels they may experience an upset stomach and diarrhea. This yeast may help in the reduction of symptoms.[19]

Crohn’s Disease[5][6]

C-diff infections[8–12][20]

Maintenance Treatment of Disease

For therapeutic treatment of clostridium difficile: in a randomized placebo-controlled trial, researchers found that saccharomyces boulardii was “shown to be an effective and safe therapy for these patients with recurrent CDD(c. difficile)”.[35]

Another study conducted in rats found that saccharomyces boulardii “may reduce some of the enterotoxic effects of toxin A by inhibiting toxin A-receptor binding.”[38]

Maintenance treatment of Crohn’s disease: a study on patients with Crohn’s disease discovered preliminary data showing that saccharomyces boulardii could be effective in the maintenance treatment of the disease.[36]

Saccharomyces Boulardii

Top 4 killers of Saccharomyces Boulardii

  • Probiotics need to be protected in enteric-coated capsules for them to be able to reach and populate the lower intestine. [1]
  • Tap Water: unfortunately, tap water isn’t great for yeast growth. It can reduce, slow or possibly stop growth altogether.[2]
  • Hot or cold temperatures: yeast grows best in warm to very warm temperatures. Although it can survive a wide range of temperatures, it begins to suffer injury at temperatures of 120 degrees Fahrenheit and will likely lose all life by 140 degrees Fahrenheit. Freezing will put the yeast in a state of suspension.[3]
  • Starvation: Yeast needs both food and salt to grow. If yeast does not have these nutrients, it will not thrive.

How Safe is it?

Saccharomyces boulardii has been found to have very minimal risk. Saccharomyces boulardii is likely safe for adults to take orally. In rare cases in subjects with weakened immune systems or in pregnant women, it may cause fungal infections that can spread through the body, as well as into the bloodstream. [18] If for whatever reason you have a weakened immune system, or for women who are pregnant/breastfeeding, caution should be used and you should consult with your physician before taking probiotics, as the side effects in these individuals are not fully known yet.

Saccharomyces boulardii is safe for use in otherwise healthy people. As with any medications or concerns consult with a physician.

Who Should Avoid Use of Saccharomyces Boulardii?

People with yeast allergies: people with yeast allergies should avoid use of saccharomyces boulardii unless advised otherwise by a physician. Saccharomyces boulardii can cause allergic reactions in these individuals.[34]

People suffering from weakened immune systems: fungemia is an infection that occurs when a yeast infection spreads to the bloodstream. People who are taking medications that negatively compromise the immune system or have a weakened immune system due to illness or disease should avoid taking saccharomyces boulardii as there have been reported cases of fungemia related to its use. [18]

How to Pick the Best Saccharomyces Boulardii Supplements

pick probiotics
How to pick the best supplement 
  • In order to reap the health benefits of saccharomyces boulardii, the supplement should have a minimum effective dose of 1 billion CFU.
  • For preservation, supplements containing saccharomyces boulardii should be freeze dried. In order to ensure that they have the opportunity to populate the lower intestine, be sure the capsules are enteric coated.
  • In this study researchers found that “alginate microspheres(i.e. microencapsulation) could be of great interest in therapeutic applications of the yeast.” In other words, it’s a good idea to ensure that whatever saccharomyces boulardii supplements you decide to buy are microencapsulated so that the supplement is bioavailable(meaning it lasts through to the intestinal tract and has its intended therapeutic effect) upon consumption.
  • For the best results we recommend looking into a blend of probiotics that include saccharomyces boulardii, along with at least 10 strains of healthy probiotic bacteria.
  • As with all supplements, it should be non-GMO, free from unnecessary fillers and binders, and made in a cGMP certified facility in the USA.
  • Probiotic supplements should be purchased from company you’ve researched and trust. Legitimate probiotic supplement vendors have simple, straight forward return policies.
  • Any high-quality supplements will be be made in a cGMP certified facility so you know they’ve been grown in sanitary conditions.

Good vs bad

How to get the most out of your supplements

  1. Choose your supplements from a reputable company.
  2. Follow the directions on the label and take the recommended dosage.
  3. Avoid taking probiotics on an empty stomach.
  4. Store probiotics properly – in most cases that means in a cool, dry place.
  5. Probiotics work best when taken in addition to a healthy diet. Probiotics are able to flourish best when they’re combined with fruits, vegetables and foods rich in fiber.

Want to Learn More?

Here are some more helpful resources on saccharomyces boulardii:


Show Sources
Share on facebook
Share on twitter
Share on pinterest
Share on email

Recommended Articles

Black text on a yellow background that says "lactobacillus bulgaricus" and a graphic of a bacterial cell

Lactobacillus Bulgaricus: A Probiotic Strain

Lactobacillus bulgaricus, also known as Lactobacillus delbrueckii subsp. bulgaricus is a member of the acidophilus group of lactic acid group of bacteria and Firmicutes phylum (1,2,3). Lactobacillus delbrueckii subsp. bulgaricus is one of the subspecies of Lactobacillus delbrueckii along with

BlueBiotics Ultimate Care Review

-EDITORS’ CHOICE-           Overall Rating:          4.8/5 What Really Sets BlueBiotics UC Apart From The Rest? For years, BlueBiotics has been the most highly recommended and most effective probiotic supplement available. With their new supplement, BlueBiotics Ultimate Care, BlueBiotics

The Top 5 Best Prebiotic Supplements of 2020

Dietary fibers contain a blend of vitamins, minerals, and antioxidants that is unlike anything else we eat. For that reason, the scientific community has studied them extensively over the past few decades. The resulting list of benefits is incredibly long

Image of a bowl of miso soup, which can contain the probiotic lactobacillus gasseri

Lactobacillus Gasseri

While bacteria are often associated with sickness, infection, and a host of other health issues, they are an essential part of a healthy GI system. The gut microbiome, consisting of countless bacteria found mostly in the large intestine, has been

Image of a container of the best prebiotic supplement, BlueBiology 100% Plant Based Prebiotic

BlueBiology Prebiotic Review

BlueBiology’s BlueBiotics Ultimate Care probiotic supplement has been our preferred probiotic supplement for some time now and it’s what we recommend the most when people ask us about probiotics. So when BlueBiology came out with their prebiotic supplement, we were

Image of the top 5 best probiotics

Top 5 Probiotics of 2020

Within the past few years, the probiotics market has been EXPLODING. Doctors may have been prescribing them for a long time, but only recently have people started including these extraordinary supplements in their daily diets. Those who have started regularly

Image of a person holding prebiotic grains

What Are Prebiotics?

Prebiotics are non-digestible fibers, carbohydrates, and certain types of sugar that act as food for probiotic microorganisms that pass through the digestive system. By eating prebiotics or taking a prebiotic supplement, you can improve the balance of microflora in your

Image of a woman holding a glass of water taking probiotic supplement bifidobacterium longum in a pill

Bifidobacterium Longum: A Probiotic Bacteria

Bifidobacterium longum is a rod-shaped, Gram-positive, anaerboic bacterium strain in the Bifidobacterium genus of the phylum Actinobacteria (1,2). Bifidobacteria are prokaryotes, which mean that they are unicellular organisms that do not have a membrane-bound nucleus, mitochondria, or membrane-bound organelle (3).

Image of yogurt on a table from above, which can contain lactobacillus casei

Lactobacillus Casei

Lactobacillus casei is a rod-shaped, gram-positive, non-spore forming bacterium strain in the Lactobacilli genus (1). It is found in many strains in lactic acid fermented food products such as sauerkraut, fermented meat and fish, sourdough, pickled vegetables, and wine as

Image of yogurt, fruit and granola in a bowl on a table, which can contain the probiotic lactobacillus rhamnosus

Lactobacillus Rhamnosus

What is Lactobacillus rhamnosus? Lactobacillus rhamnosus GG is a form of naturally occurring bacteria that is commonly found in the genital and urinary tract of human females. It is one of the most widely used probiotic strains, and is often

Leave a Comment